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Diclofenac may decrease the antihypertensive activities of Nebivolol. According to the founding myth of the city by the Ancient Romans themselves, [16] the long-held tradition of the origin of the name Roma is believed to have come from the city's founder and first king, Romulus. Generali JA, Cada DJ (August 2009). Mouse models in which the genes for AMPKО±1 and О±2 catalytic subunits ( Prkaa1/2) or LKB1, an upstream kinase of AMPK, had been knocked out in hepatocytes, have raised doubts over the role of AMPK, since the effect of metformin was not abolished by loss of AMPK function. Tramadol is also a potential interacting medicament. Table 5 for Magnitude of Interaction.